contains all CO2-soluble lipohilic and semipolar components

Raw material:
Commiphora mukul - Gum resin

Production:
By supercritical CO2 extraction with small amount of ethanol as entrainer, no inorganic salts, no heavy metals, no reproducible microorganisms [1]. The extract is standardised with MCT-oil, a food grade medium chain triglyceride.

Extract:
yellow brown, clear to slightly turbid viscous oil with weak typical smell

D/E-ratio:
3,0 - 4,0 kg raw material yield 1 kg product.

Declaration:
INCI-Name (CTFA): Commiphora Mukul (Guggul) Resin Extract, CAS-No. 93165-11-8, EINECS-No. 296-895-2 and Caprylic/Capric Triglyceride, CAS-No. 73398-61-5, EINECS-No. 277-452-2

Transport data:
No dangerous good in the sense of the transport regulations.

Ingredients:
1,9 - 2,1 % Guggulsterones analysed by HPLC, 6 - 9 % sum of phytosterols, mainly sitosterol, small amount of essential oil, cembrene and mukulol (allycembrol), less than 3 % of ethanol

Application:
In cosmetics:
The product has restorative efficacy and is recommended for treating degenerative skin conditions and wrinkle formation. It has anti-inflammatory, rejuvenating and energising properties. It stimulates fibroplast proliferation, enhances type I collagen synthesis, inhibits matrix metalloproteinases and elastase expression [2]. It is also suggested for irritated skin and anti-cellulite products.

In food supplements:
Guggul extracts have shown hypocholesterolemic, hypolipidemic, hypolipoproteinemic, anti-cancer, anti-inflammatory and anti-diabetic efficacy [3]. The present product was tested in-vitro and shown to inhibit HMG-CoA reductase activity and cholesterol biosynthesis, improve the HDL/LDL ratio, inhibit alpha-glucosidase activity and induce cellular glucose uptake. Additionally it demonstrates anti-adipogenic efficacy by inhibition of pre-adipocyte differentiation and lipolysis of adipocytes. It regulates glucose metabolism as well as fat burning by enhancing AMPK activity and modulation of downstream intracellular and mitochondrial molecular mechanisms. Accordingly it is suggested for complimentary therapy not only in case of hyperglycemia and type-II diabetes but also hypercholesterolemia, obesity and the metabolic syndrome.

(Statements summarise literature evidence and have informative character. They might be derived from invitro or animal testing and not be substantiated for humans. They don’t warrant end product properties. Statements have not been evaluated by the FDA. Formulations with this extract are not intended to diagnose, treat, cure or prevent any disease.)

Naturalness:
The product is manufactured from the named raw material and 100 % natural.  It contains apart from MCT-oil no other additives  and no other technical adjuncts. 

Stability:
Closed pack under cool and dry storage conditions and exclusion of light at least  5 years.

[1] Manninen P., Häivälä E., Sarimo S., Kallio H. : Z. Lebens Unters Forsch A (1997) 204: 202-205
[2] Ramachandran C., Quirin K. W., Resek A.  and Melnick S. J.: International Journal of Cosmetic Science (2012) 34, 155-160
[3] Shishodia S., Harikumar K.B., Dass S., Ramawat K.G., Aggarwal B.B.: Anticancer Research (2008) 28: 3647-3664

These data are given for customer´s information only to the best of our knowledge but under exemption of liability especially regarding infringement of or prejudice to third party rights through the use of this product. This information is not a substitute for prior tests demonstrating the suitability of the product for the intended use. Users are responsible for ensuring the compliance with the applicable legislation. The concentrated FLAVEX extracts are raw materials for product formulation. Hence they are not intended for direct consumption in food and for undiluted topical application in cosmetics, perfumery and aromatherapy. Keep away from children.

Version 66.434.01, 12.01.2012

Download: General Specification

Download: MSDS