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Rosemary Antioxidant extract 14, water dispersible
Product-No.: 027.003


Raw Material:
Salvia rosmarinus – Leaves, dried

Production:
By supercritical fluid extraction with natural carbon dioxide and a small amount of alcohol as entrainer, no inorganic salts, no heavy metals, no reproducible microorganisms [1]. The CO2 – extract is standardised on diterpene phenols with sunflower oil. It is water dispersible by formulation with the emulsifier Polysorbat 80.

Ingredients:
7 – 10 % Antioxidative reference compounds: phenolic diterpenes carnosic acid and carnosol calculated as carnosic acid with > 6 % of carnosic acid, content of alcohol < 1,5 %, cuticular waxes, contains sunflower oil and the emulsifier Polysorbat 80 as additives.

Application:
Traditional Use: Rosemary (Rosmarinus officinalis) has been used in Europe since ancient times as tonic, stimulant, and carminative to treat dyspepsia, headaches and nervous tension. The ancient Greeks used it to strengthen memory function and concentration. In India, rosemary leaves are used in Ayurvedic Medicine for treatment of flatulent dyspepsia associated with psychogenic tension and migraine headaches.In Cosmetics and Foods:Rosemary CO2-Antioxidant has antioxidative, antimicrobial and anti-inflammatory properties. It retards oxidation of fatty oils, carotenoids and essential oils and it is used in food industry (dressings, sausages, snacks,etc.), in food supplements and in cosmetics. Dosage 0,05 – 0,1 % in case of saturated fats, 0,2 – 0,4 % in case of polyunsaturated oils. EU declaration, if used in food and supplements: Natural Antioxidant Rosemary Extract or Natural Antioxidant E 392.A screening for antimicrobial activity of Rosemary CO2-Antioxidant by disk diffusion assays and agar dilution tests demonstrated a broad spectrum of activity against 28 germs, different Staphylococcus and Streptococcus, Corynebacterium and Pseudomonas species as well as against Bacillus subtilis, Micrococcus luteus, Propionibacterium acnes and Candida species in concentrations as low as 0,1 % or less. The efficacy against gram positive bacteria was superior to gram negative bacteria and fungi with a 5 to 10 fold higher minimal inhibitory concentration [2]. Rosemary CO2-Antioxidant has also anti-aging properties. Topical application inhibits the oxidation of polyunsaturated fatty acids in membranes and the non-enzymatic glycosylation of proteins.Also anti-inflammatory, cytostatic and cytotoxic activities of Rosemary extract when applied topically are described [3-4].In Food Supplements:A significant number of in vitro and in vivo studies provide evidence that Rosemary extract and its bioactive Diterpene Phenols (DTPs) have anticancer [5], antidiabetic [6], antioxidant [6-7], antiulcerogenic [8] and hepatoprotective [9-10] effects. In vitro and in vivo trials demonstrate also improvement of cognitive deficits [11]. Diterpene Phenols (DTPs) of Rosemary have shown in vitro and in vivo to inhibit neuronal cell death. The multifunctional nature of the compounds from the general antioxidant-mediated neuronal protection to other specific mechanisms including brain inflammation and amyloid beta (Aß) formation, polymerisation, and pathologies is discussed. The therapeutic potential of these compounds for Alzheimer´s disease (AD) should be considered [12].*

Literature:
[1] P. Manninen, E. Häivälä, S. Sarimo, H. Kallio : Distribution of microbes in supercritical CO2 extraction of sea buckthorn (Hippophae rhamnoides) oils : Zeitschrift für Lebensmitteluntersuchung und -Forschung / Springerverlag (1997) 204: 202-205
[2] Committee on Herbal Medicinal Products (HMPC), European Medicines Agency (EMA) : Community herbal monograph on Rosmarinus officinalis L., aetheroleum : EMA/HMPC/235453/2009
[3] Wolfgang Blascheck u.a. (Hrsg.) : HagerROM 2017, Hagers Enzyklopädie der Arzneistoffe und Drogen : Suttgart: Wissenschaftliche Verlagsgesellschaft Stuttgart, 2017
[4] European Food Safety Authority : Use of rosemary extracts as a food additive : The EFSA Journal (2008) 721, 1-29
[5] Simona Birtic, Pierre Dussort, François-Xavier Pierre, Antoine C. Bily, Marc Roller : Carnosic acid : Phytochemistry 115 (2015) 9–19

* Statements summarise literature evidence and have informative character. They might be derived from in vitro or animal tests and thus not be substantiated for humans. Statements have not been evaluated by competent authorities and do not refer to finished products. The marketer of any finished product containing any FLAVEX extract as ingredient is responsible for assuring that the claims made for his product are lawful and comply with all applicable laws and regulations of the country in which the product is to be sold.