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Flavex Naturextrakte GmbH
Nordstraße 7
D-66780 Rehlingen
Tel.: +49 (0) 68 35 / 91 95 - 0
Fax: +49 (0) 68 35 / 91 95 - 95
E-Mail: info@flavex.com


Curcuma Longa CO2-to extract (organic), DE-ÖKO-013
Product-No.: 094.005
 
Raw material:

Curcuma longa - Rhizome, dried, from organic farming


Production:

By supercritical fluid extraction with natural carbon dioxide, no solvent residues, no inorganic salts, no heavy metals, no reproducible microorganisms [1].


Ingredients:

70 - 90 % essential oil containing mainly alpha- and beta-turmerone and ar-turmerone; in addition alpha-phellandrene, alpha-zingiberene, sesquiphellandrene. The extract contains only traces of curcumin.


Application:

Traditional Use:

Curcuma is an important seasoning and in traditional Chinese medicine and Ayurvedic medicine, turmeric has been used to aid digestion and in treatment of liver and bile problems, it helps relieve arthritis pain, and regulate menstruation. Today, traditional or folk uses of turmeric include heartburn, dyspepsia, stomach ulcers, gallstones, inflammation, and cancer.

In Cosmetics:

In an animal study curcuma longa (turmeric) essential oil shows in dermal application good efficacy in inhibition of Trichophyton-induced dermatophytosis in guinea pigs [2].

In Food Supplements:

Although the product does not contain the polar curcuminoids, which have the yellow colour, nevertheless the essential oil of curcuma contributes to the therapeutic healing effect since it increases the bioavailability of the curcuminoids [3, 4]. Some promising effects of curcuminoids in clinical trials are treatment of various pro-inflammatory diseases including cancer, cardiovascular disease, arthritis, irritable bowel disease, tropical pancreatitis, peptic ulcer, gastric ulcer, gastric inflammation, atherosclerosis, diabetes, diabetic nephropathy, acquired immunodeficiency syndrome (AIDS). Curcuminoids have also shown protection against hepatic conditions and alcohol intoxication [5].

One or more animal studies or clinical trials of curcuma longa (turmeric) essential oil show efficacy in:

-amelioration of ischemia-induced neurological functional deficits [6].

-neuroprotective activity against cerebral ischemia for treatment of cerebral stroke and other disorders associated with oxidative stress [7].

-inhibition of the development of increased blood glucose and abdominal fat mass in obese, diabetic rats when simultaneously curcuminoids are administered [8].

-treatment of disorders of the respiratory tract, e.g. removing sputum, relieving cough, and preventing asthma [9].

Mechanism of Activity

The essential oil of Curcuma longa has a high concentration of the bioactive turmerones. The turmerones have shown in vitro the following activities: inhibition of NF-?B activation in TPA-induced breast cancer cells [10], inhibition of key enzymes linked to type 2 diabetes [11], anti-inflammatory effects in microglial cells [12], apoptosis of human hepatocellular carcinoma [13], anti-inflammatory effects in amyloid ß-stimulated microglia [14], anti-proliferative and immunomodulatory activities [15], activation of apoptotic protein [16].
(Statements summarise literature evidence and have informative character. They might be derived from in vitro or animal tests and thus not be substantiated for humans. Statements have not been evaluated by competent authorities and do not refer to finished products. The marketer of any finished product containing any FLAVEX extract as ingredient is responsible for assuring that the claims made for his product are lawful and comply with all applicable laws and regulations of the country in which the product is to be sold.)


Literature:
[1] P. Manninen, E. Häivälä, S. Sarimo, H. Kallio : Distribution of microbes in supercritical CO2 extraction of sea buchthorn (Hippophae rhamnoides) oils : Zeitschrift für Lebensmitteluntersuchung und -Forschung / Springerverlag (1997) 204: 202-205
[2] Apisariyakul A, Vanittanakom N, Buddhasukh D. : Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae) : J Ethnopharmacol. 1995;49:163?9
[3] Yue GG, Cheng SW, Yu H, Xu ZS, et al. : The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. : J Med Food. 2012 Mar;15(3):242-52.
[4] Prasad S., Aggarwal BB. : Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Chapter 13: Turmeric, the Golden Spice From Traditional Medicine to Modern Medicine Benzie IFF, Wachtel-Galor S, editors. :
[5] Gupta SC, Patchva S, Aggarwal BB. : Therapeutic roles of curcumin: lessons learned from clinical trials. : AAPS J. 2013 Jan;15(1):195-218.
[6] Dohare P, Garg P, Sharma U, Jagannathan N. R, Ray M : Neuroprotective efficacy and therapeutic window of curcuma oil in rat embolic stroke model : BMC Complement Altern Med. 2008;8:55
[7] Rathore P, Dohare P, Varma S. et al. : Curcuma oil reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain : Neurochem Res. 2008;33:1672?82
[8] Honda S, Aoki F, Tanaka H. et al. : Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: A DNA microarray study. : J Agric Food Chem. 2006;54:9055?62
[9] Li C, Li L, Luo J, Huang N. : Effect of turmeric volatile oil on the respiratory tract : Zhongguo Zhong Yao Za Zhi. 1998;23:624?5.
[10] Park SY1, Kim YH, Kim Y, Lee SJ. : Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-?B activation in TPA-induced breast cancer cells. : J Cell Biochem. 2012 Dec;113(12):3653-62.
[11] Lekshmi PC1, Arimboor R, Indulekha PS, Menon AN. : Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. : Int J Food Sci Nutr. 2012 Nov;63(7):832-4.
[12] Park SY1, Kim YH, Kim Y, Lee SJ. : Aromatic-turmerone's anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling. : Neurochem Int. 2012 Oct;61(5):767-77
[13] Cheng SB1, Wu LC, Hsieh YC, Wu CH, Chan YJ, Chang LH, Chang CM, Hsu SL, Teng CL, Wu CC. : Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. : J Agric Food Chem. 2012 Sep 26;60(38):9620-30
[14] Park SY1, Jin ML, Kim YH, Kim Y, Lee SJ. : Anti-inflammatory effects of aromatic-turmerone through blocking of NF-?B, JNK, and p38 MAPK signaling pathways in amyloid ?-stimulated microglia. : Int Immunopharmacol. 2012 Sep;14(1):13-20.
[15] Yue GG, Chan BC, Hon PM, Lee MY, Fung KP, Leung PC, Lau CB. : Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2011-20
[16] Lee Y. : Activation of apoptotic protein in U937 cells by a component of turmeric oil. : BMB Rep. 2009 Feb 28;42(2):96-100.


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